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Separately, someone also walks up to Tung, who closes his eyes. A person approaches the mistress and her son. Tung asks her to wait while he looks for the means of escape. They arrive at a beach, presumably to escape via boat. Tung attempts to flee with Lung's mistress and their baby son. While Soso is serving prison time, assassins disguised as painters slit her throat.
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He intimidates the police by firing the weapons in the air, and is shot to death. Refusing to surrender to the police, Lung walks out of the warehouse, armed with machine guns. While dying, Tin-hung expresses that he forgives Lung, and hopes that he will soon join him after he dies. The fight ends with Lung impaling Tin-hung with a pipe. Knowing that they will be unable to escape, Tin-Hung mentions that he was never convinced by the stories that claim Lung was an "invincible fighter." Lung accepts Tin-hung's challenge. Lung and Tin-hung are trapped in a warehouse and surrounded by the police outside.
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Lung catches up to Soso whom he refuses to kill, after she expresses her bitterness about her inability to conceive and Lung's decision to have a child with a mistress. Soso and Fat's men are killed, while Tung executes Fat. Lung goes after the couple, resulting in a shootout. Tung learns about Soso and Fat's role in Yu's killing. Later, Lung has a meeting with his rival, Flirt (Tam Ping-man), a gang leader who reveals he had nothing to do with Yu’s death. Lung and Tung eventually start a war against a rival triad gang whom they suspect is responsible for the murder. After receiving $200 million from Lung, Soso and Fat kill the hired kidnappers and Uncle Yu to cover their tracks. They orchestrate a kidnapping of Lung's financial backer, Uncle Yu (Hui Shiu-hung). It is revealed that Soso and gang member Law Ting-Fat are blackmailing Lung and his gang. Various police officers and Triad gang members are killed as the Triads try to escape the precinct. The gang executes Tracy’s lover, and breaks into police headquarters to assassinate Wu. Later that night, Tung and Tin-hung torture Tracy, who reveals that the threat was bogus and that her secret lover coerced her into creating a lie so she could flee with him once she had received the money. Wu remains uncooperative with the police and his wife Tracy (Pinky Cheung) talks with Lung's wife Soso (Tien Niu), threatening to have Wu expose Lung's gang if she does not receive $20 million. A gunfight ensues between the police and triads, resulting in Wu’s arrest. Police officers raid a drug shipment involving Lin Ho-tung (Simon Yam), Lung's right-hand man and assassin, Lok Tin-hung (Wu Jing), and Wu (Ken Lo), a drug dealer. The party is interrupted when Police Inspector Liu Chi-chung (Danny Lee) arrives outside of the club with his colleagues, warning the gang to stop throwing any parties without the police's consent. In this context, we will discuss how the membrane-acting toxins called cytolysins can be a potential new tool for GBM treatment.Triad boss Lin Ho-lung (Sammo Hung) is celebrating his son's first birthday, a child conceived by his mistress. Finally, GBM patient prognostic has shown little improvement in decades. These cancer therapies, while killing the majority of tumor cells, ultimately fail in GBM treatment because they do not eliminate GSCs, which survive to regenerate new tumors. A sub-population of cells with stem-like properties may be the source of tumors since, apparently, GBM stem cells (GSCs) are highly resistant to current cancer treatments. These singular properties of GBMs will be described here.
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However, little is known about the immune performance and interactions of the microglia with GBMs. Another interesting aspect is that, inside the GBM tissue, there are up to 30% of microglia or macrophages. The invasion process includes the overexpression of several members of a super-family of zinc-based proteinases, the Metzincin, in particular a sub-group, metalloproteinases. GBM cells have the ability to infiltrate and disrupt physical barriers such as basement membranes, extracellular matrix and cell junctions. One of the first steps in tumor invasions is migration. Angiogenesis in GBMs is correlated with the grade of malignancy and is inversely correlated with patient survival. Moreover, GBMs are among the most vascularized and invasive cancers in humans. Glioblastomas (GBMs) are considered to be one of the deadliest human cancers, characterized by a high proliferative rate, aggressive invasiveness and insensitivity to radio- and chemotherapy, as well as a short patient survival period.